Extended photodynamic therapy to treat cancer
At the so-called photodynamic therapy for the treatment of Krebs Using light, the active ingredients are targeted directly on the Tumor activated. So far, the method can only be used to a limited extent because the principle places high demands on an active ingredient. However, a Japanese research team has now succeeded breakthrough in this area.
A working group of University of Tokyo Institute of Industrial Sciences presented a new photodynamic approach to cancer treatment. The results of the study were recently presented in the journal Chemical Communications.
What are photodynamic therapies?
Photodynamic therapy is currently only used for external tumors that have not penetrated the skin more than three millimeters. The treatment is considered relatively gentle, as healthy tissue is largely unaffected.
Acidic environment inhibits effectiveness
In an application against internal tumors, however, the research groups encountered previously insurmountable obstacles, as the potential active ingredients must penetrate the tissues. Red light be activated and on the other hand in a low oxygen environment function usually present in tumours.
However, conventional photodynamic techniques have so far been limited to the formation reactive oxygen species responsible for destroying tumor cells. This low oxygen environment cancer cells, however, thwarted the formation of such radicals.
Alkyl radicals do not depend on oxygen
With the new method, the ace Photo-uncaging-System is called, the researchers tackle this problem by administering the active substance in an inactive form and acting on the spot only with the help of red light.
In doing so, supposedly Alkyl radicals published. These radicals, unlike oxygen radicals, can cause cell death both in the presence of oxygen and in the absence of oxygen. For the first time, the working group used molecules called “Organorhodium(III)-phthalocyanine(Pc)-complex“to be designated.
A red light laser activates the complexes
“The complexes we have developed are very stable during synthesis, purification and measurement under ambient light, but can be activated by a laser that emits pulses of red light at the nanosecond scale”explains the first author of the study To Murata.
Moreover, these lasers, which emit pulses in a billionth of a second, are relatively easy to use, according to Murata.
In the laboratory, the team has already been able to demonstrate that the active ingredients released by activating the organorhodium(III) phthalocyanine (Pc) complexes using a red light laser effectively kill cancer cells to be able.
“Our new technology could enable the photochemical generation of a variety of alkyl radicals and aldehydes, which would allow the local release of various bioactive molecules”summarizes the author of the study Kazuyuki Ishii.
According to the research team, the presented model represents an improvement over other photo-decaging systems and opens up new avenues for cancer treatment. Phototherapy. (vb)
Author and source information
This text corresponds to the requirements of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.
Graduate editor (FH) Volker Blasek
- University of Tokyo: Radical new treatment system sheds light on cancer therapy (veröffentlicht: 21.09.2022), iis.u-tokyo.ac.jp
- Kei Murata, Yuki Saibe, Mayu Uchida, et al. : Two-photon red light deblocking of alkyl radicals of organorhodium(iii) phthalocyanine complexes; in: Chemical Communications (2022), pubs.rsc.org
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.